Nursing, Pharmacology and Healthcare

Orthopedic Assessment and Management

Proteus syndrome (PS) causes asymmetric, disproportionate, and severe postnatal overgrowth, particularly bone, in a mosaic pattern. Although skeletal features predominate, the disease may affect any tissue and lead to the overgrowth of brain, skin, adipose, and vasculature, immune, gut, and other tissues. The cause of Proteus syndrome (PS) is unknown, but it is hypothesized that it is caused by a new, mosaic, mutation acquired early in development; cells derived from the mutated cell line carry this mutation and result in affected tissues.